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http://www.dfwcfids.org/medical/cheney/heart04.part1b.htm
The Heart of the Matter:
CFS & Cardiac Issues
Part 1b
Top Priority: Blood Pressure
"Now there is one factor that I want to mention before I get into the data display. Natelson requires, as a rule, before you're allowed into his medical school for study (whether it's this particular study or any other study) that you consider coming off of all medications and all nutraceuticals or he may not see you. Furthermore, his team is not treatment oriented."
Dr. Cheney continues: "Of course you wouldn't agree. Therefore, the data I'm about to present is not anywhere near as bad as you are." You are more severely affected than anyone in this study. I'm not sure he has patients from the truly severe end of the spectrum of CFS. Those patients don't participate in studies. Just reflect on that as I go through this.
In this study, the normal person and the non-disabled CFIDS patient pump 7 liters a minute through their heart with very little variance: 7 liters plus or minus .5. When they stand up, they drop all the way down to 5 liters per minute, a full 30% drop in output. That's normal.
"First of all, why does it go down when you stand up? Because the heart can only pump as much blood as returns to it. If you drop the return by 2 liters per minute, you will always drop the output by 2 liters per minute. The blood has to go uphill against gravity, so there's an automatic 2 liter per minute drop in return, and therefore an automatic 2 liter drop in output even though the heart is completely normal. Where does that extra 2 liters go? It's pooled in your lower extremities and capacitance vessels. Rapidly, by the way." [Capacitance vessels are the larger veins of the body where most of…………………………………
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….First Compromised: Skin and Compensatory Hypothyroidism
Having said this, in what order are things sacrificed and what are the consequences? The first is the skin. If you sacrifice the microcirculation of the skin, several problems can arise. One is that without adequate microcirculation to the skin, the body cannot thermoregulate anymore. [Thermoregulate: regulate body temperature]
You cannot stand heat or cold, although heat will be more difficult at first than cold—in part because if you're too cold you just put on more clothes, but how do you rip your skin off when you get too hot? If your core temperature rises high enough, you will not sleep and your body will activate your immune system. In order to regulate that problem, your body will kick in thyroid regulation and you will downregulate [reduce or suppress a response to a stimulus] your thyroid to keep your temperature from going too high, and you will develop "compensatory hypothyroidism"! Now you will have trouble with cold.
The second thing your body will not be able to do is get rid of VOCs (Volatile Organic Compounds), which are shed in the skin's oil ducts. VOCs build up in the fat stores of your body and you become progressively chemically poisoned by whatever is present in your environment, and whatever you are genetically susceptible to—different things in different people. If that's pretty significant, we call that Multiple Chemical Sensitivities (MCS). If all you've got is microcirculatory deficiency of the skin, we'll call that MCS and the treatment is to put you in a sauna to outgas you—to detoxify you—which is in fact the primary treatment of MCS patients. We'll also exercise you, which is another MCS treatment.
Next Up: Muscles
If it gets worse than that, the next thing you'll sacrifice are your muscles. You'll have exercise intolerance—you can't go up stairs or climb mountains as easily. When you move your muscles, you feel like you got hit by a ten-ton truck. Very minor activity on day one produces a day two on which you say, "What did I do, it's almost like I ran a marathon."
If it gets still worse, you begin to get fibromyalgic pain. If it affects the joints, it may precipitate pyrophosphoric acid and uric acid crystals and you start to have arthralgias and myalgias linked to this microcirculatory defect. Microcirculation problems have been suggested by Fibromyalgia research in Toronto.
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Third System Down: Liver/Gut
The next thing affected is your liver/gut. Probably the very first thing you'll notice is that there are fewer and fewer foods you can tolerate. If it gets really bad, there will be only a handful of foods you'll be able to eat—for a lot of odd reasons. In part because microcirculation is necessary for proper digestion. Also, your body won't secrete digestive juices so you won't digest your food. If you can't digest your food you'll get peptides that are only partially digested and highly immune-reactive. They'll leak out of your gut [into your bloodstream] and you'll get food allergies and/or sensitivities.
Your body will also fail to detoxify your gut ecology, so your gut will begin to poison you. That's manifested as feeling yucky and a sense of toxic malaise. You get diarrhea, constipation, flatulence, and all kinds of GI problems, including bacterial overgrowth, yeast overgrowth, parasitic overgrowth.
It's a problem because you have poor microcirculation. If it gets worse, you'll get malabsorption syndromes because the nutrients that are—by some miracle—digested, are not absorbed well because there's no microcirculation. At which point, you will begin to become increasingly toxic, which can manifest as a variety of skin disturbances, and you don't feel good, and other interesting things—particularly in the brain.
Fourth Affected: The Brain
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…The brain and the heart probably get hit about the same time, but patients usually notice their brain being affected much earlier than their heart. That's because heart muscle cells have the greatest mitochondrial content of any tissue in the body. Thus, when mitochondria are impaired, the heart muscle has the greatest reserve and is the least vulnerable. Neurons have far less mitochondria and they run out long before the heart, especially if you're sedentary. If you're sedentary there's not too much demand on your heart, but you can still think and make great demands on your brain. Energy is energy, whether it's being used physically or cognitively. The effect on the brain is noticed first because it has less reserve, especially if you're thinking—unless you do meditation. Patients who are both sedentary and meditating regularly may actually preserve their brain longer than those who are just sedentary and use their brain a lot
Fifth: Heart—A Two-Parter
Part A: Manifestation of Microcirculatory Impairment
The effect on the heart has an "a" part and a "b" part. "The initial manifestation of microcirculatory impairment of the heart is arrhythmia. What kind? You name it, you've got it."
"You'll also notice, again, exercise intolerance, because the heart is indeed a muscle just like your leg muscle. When you go up flights of stairs or up mountainsides, you need more cardiac output and you can't sustain it. Therefore, you're going to have trouble. As it gets worse, you'll begin to see mitral valve prolapse (MVP) because that inadequate capillary function affects the papillary muscle and results in prolapse of the mitral valve. Finally, when you get even more severe microcirculation problems, you start to get chest pain as you begin to knock off myocardial cells [heart muscle cells] because they can't get adequate oxygen."
Part B: "The Event Horizon"
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Sixth System: Lung & Kidney
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PAUL CHENEY2° PARTE-consigli |