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uonderuoman.
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ultimo - pubmed In Vivo. 2009 Jul-Aug;23(4):621-8.
abstract:
Sheedy JR, Wettenhall RE, Scanlon D, Gooley PR, Lewis DP, McGregor N, Stapleton DI, Butt HL, DE Meirleir KL.
Vrije Universiteit Brussel, MFYS, Pleinlaan 2, 1050 Brussels, Belgium. [email protected].
Patients with chronic fatigue syndrome (CFS) are affected by symptoms of cognitive dysfunction and neurological impairment, the cause of which has yet to be elucidated. However, these symptoms are strikingly similar to those of patients presented with D-lactic acidosis. A significant increase of Gram positive facultative anaerobic faecal microorganisms in 108 CFS patients as compared to 177 control subjects (p<0.01) is presented in this report. The viable count of D-lactic acid producing Enterococcus and Streptococcus spp. in the faecal samples from the CFS group (3.5x10(7) cfu/L and 9.8x10(7) cfu/L respectively) were significantly higher than those for the control group (5.0x10(6) cfu/L and 8.9x10(4) cfu/L respectively). Analysis of exometabolic profiles of Enterococcus faecalis and Streptococcus sanguinis, representatives of Enterococcus and Streptococcus spp. respectively, by NMR and HPLC showed that these organisms produced significantly more lactic acid (p<0.01) from (13)C-labeled glucose, than the Gram negative Escherichia coli. Further, both E. faecalis and S. sanguinis secrete more D-lactic acid than E. coli. This study suggests a probable link between intestinal colonization of Gram positive facultative anaerobic D-lactic acid bacteria and symptom expressions in a subgroup of patients with CFS. Given the fact that this might explain not only neurocognitive dysfunction in CFS patients but also mitochondrial dysfunction, these findings may have important clinical implications.
PMID: 19567398 [PubMed - in process]
pubblicazioni De Meirleir et all- pubmed :
http://www.ncbi.nlm.nih.gov/sites/entrez?c...u%5D&dispmax=50
anno 2009
Severe Versus Moderate Criteria for the New Pediatric Case Definition for ME/CFS.
Jason L, Porter N, Shelleby E, Till L, Bell DS, Lapp CW, Rowe K, De Meirleir K.
Child Psychiatry Hum Dev. 2009 Jun 10. [Epub ahead of print]
PMID: 19513826 [PubMed - as supplied by publisher]
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A comparison of patients with chronic fatigue syndrome in two "ideologically" contrasting clinics.
Van Houdenhove B, Van Hoof E, Becq K, Kempke S, Luyten P, De Meirleir K.
J Nerv Ment Dis. 2009 May;197(5):348-53.
PMID: 19440108 [PubMed - indexed for MEDLINE
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Detection of herpesviruses and parvovirus B19 in gastric and intestinal mucosa of chronic fatigue syndrome patients.
Frémont M, Metzger K, Rady H, Hulstaert J, De Meirleir K.
In Vivo. 2009 Mar-Apr;23(2):209-13.
PMID: 19414405 [PubMed - indexed for MEDLINE]
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Aly Chiman17.
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