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Poliovirus Induces an Early Impairment of Mitochondrial Function by Inhibiting Succinate Dehydrogenase Activity http://www.sciencedirect.com/science?_ob=A...7614f4ca93691f4
Inhibition of mitichondrial function during Poliovirus infection (Dr Michael Carter, University of Surrey)
Carter and his team have been examining how a persistent virus infection could affect the functioning of the cell. Their most recent work has focused on the effect of poliovirus, a member of the enterovirus family, on the energy-producing compartment of cells.
,..It is known that energy is released by a flow of electrons, so it is possible to find out at which step any blockage is occurring.
Carter has found that the effect of viral infection is blocking energy production mainly at ( or just past) the second stage, i.e. blocking the transport of electrons to the third stage.
Using special dyes, it was shown that mitochrondrial function is dramatically altered by poliovirus infection.
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MITOCONDRIricerche disfunzioni |